Transcriptome Analysis of the Nematodes Caenorhabditis elegans and Litoditis marina in Different Food Environments

Diets regulate animal development, reproduction, and lifespan. However, the underlying molecular mechanisms remain elusive. We previously showed that a chemically defined CeMM diet attenuates development promotes longevity of C. elegans, but whether it impacts other nematodes is unknown. Here, we studied effects on marine nematode Litoditis marina, which belongs to same family as elegans. further investigated genome-wide transcriptional responses OP50 diets for both nematodes, respectively. observed attenuated L. marina did not extend its Through KEEG enrichment analysis, found many FOXO DAF-16 signaling lysosome xenobiotic metabolism related genes were significantly increased in elegans diet, might contribute lifespan extension Notably, expression pathway was down-regulated CeMM, explain why could promote compared bacterial feeding. Additionally, down-regulation several RNA transcription protein generation processes only be involved extending longevity, also attenuating while unsaturated fatty acids synthesis slow down growth CeMM. This study provided important insights into how different lifespan, genetic analysis candidate gene(s) will facilitate exploring physiology health context variable nutritional environments.